Adoptive T cell transfer of autoimmune nonobese diabetic mouse diabetes does not require recruitment of host B lymphocytes.

摘要: The autoimmune nonobese diabetic mouse, a model of human juvenile type I diabetes mellitus, exhibits features both B and T cell autoreactivity against insulin-producing cells. Using the neonatal transfer disease, which we have described previously, shown that suppression newborn recipients by anti-mu treatment did not affect means cell-depleted, purified cells from adults were injected into newborns treated with either IR-52, control rat myeloma protein, or LOMM.9, anti-mouse mu-chain mAb. Both groups developed over similar time scale. Although pancreases in showed massive infiltration lymphocytes, presumably recruited host, present IR-52-treated group, whereas they absent LOMM.9-treated group. Anti-mu-treated animals substantial vivo vitro when compared controls. These results suggest is secondary phenomenon unimportant during effector phase mice.