Hepatic Histology and Morphometric Measurements in Idiopathic Extrahepatic Portal Vein Thrombosis in Children, Correlated to Clinical Outcome of Meso-Rex Bypass.

摘要: OBJECTIVE The aim of this study was to correlate clinical, histologic, and morphometric features the liver in children with extrahepatic portal vein thrombosis (EHPVT), surgical outcome after Meso-Rex bypass (MRB). BACKGROUND Idiopathic EHPVT, a significant cause hypertension, is surgically corrected by MRB. Correlation histologic has not been reported children. METHODS We retrospectively reviewed clinical intraoperative data 45 idiopathic EHPVT. Liver samples were obtained at time Morphometric measurements tract structures performed correlated outcome. Median follow-up 3.65 years surgery (range 1.5 10 years). RESULTS Thirty-seven (82.2%) had successful There no association between age, sex, suture material Average patient age higher patients postoperative complications (P = NS). Portal fibrosis, bridging, parenchymal nodules, inflammation, hepatocellular swelling, steatosis, dilatation lymphatics, periductal fibrosis did show difference 2 groups. bile duct area index significantly smaller unsuccessful group (P = 0.004 0.003, respectively). A <0.08 lower chance Hepatic artery different. Measured blood inflow only factor affecting 0.0003). CONCLUSIONS Low may be negative prognostic factors for MRB higher, although statistically significant, complications.