A comparative histological and morphometric study of vascular changes in idiopathic portal hypertension and alcoholic fibrosis/cirrhosis.
作者： K Tsuneyama , K Ohba , Y Zen , Y Sato , H Niwa
DOI: 10.1046/J.1365-2559.2003.01658.X
关键词:
摘要: Aim: To examine the pathological changes of hepatic arteries in idiopathic portal hypertension (IPH) which is characterized by obliteration intrahepatic vein branches and presinusoidal hypertension. Methods results: Liver specimens (biopsied or surgically resected) from 20 patients with IPH, alcoholic fibrosis/cirrhosis (AF/C) histologically normal livers were used. The vascular lumina arterial venous vessels tracts morphometrically evaluated an image analysis system. ratio luminal area to tract (portal index) IPH that AF/C significantly reduced compared liver. index for was lower than AF/C. higher liver; however, similar normal. peribiliary plexus increased but not IPH. In AF/C, number mast cells macrophages known be source angiogenic substances liver, while it increased. Conclusions: a reduction lumen associated increase angiogenesis-related tracts. However, such compensatory evident this failure may feature
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