Lipid pattern in middle-aged inhabitants of the Lower Silesian region of Poland. The PURE Poland sub-study.

摘要: Introduction. A decreased serum high density lipoprotein-cholesterol (HDL-C) is a strong predictor of cardiovascular risk. However, total HDL very dynamic, changeable fraction, and does not perform the function atherosclerosis markers. In presented study, pattern lipids, including HDL-C subclasses (HDL2- HDL3-cholesterol), in middleaged Polish Lower Silesia population was defined. Materials method. group 746 males 1,298 females, aged 35–70, were investigated. All subjects participants PURE study. Mean lipid levels determined for groups selected on basis gender, age, cigarette smoking, drinking alcohol place residence (urban/rural area). The data analyzed using STATISTICA 6.0 PL. Results. multiple linear regression models, age most important independent consistent cholesterol (TC) LDL (LDL-C). prevalence low (threshold 40 mg/dL males, 50 females) 16.5% 22.6% females. This gender-conditioned difference greater rural (20.0% vs. 30.9%, respectively, comparison to urban (14.4% 17.1%) areas. significantly worse than Female inhabitants showed higher triglycerides (TG) lower (total contained HDL2 HDL3). Simultaneously, BMI, percent smokers drinkers smoking female females estimated. population, or associated with significant increases TC, LDL-C TG, also (smoking) HDL2-C (drinking). Two-way analysis variance existence interaction between these risk factors their influence HDL3-C. Conclusion. middle-aged Silesian region Poland area) had impact pattern. more atherogenic women women.