Phosphate repression of cephamycin and clavulanic acid production by Streptomyces clavuligerus
作者： Ahmed Lebrihi , Pierre Germain , G�rard Lefebvre
DOI: 10.1007/BF00253896
关键词:
摘要: Production of cephamycin and clavulanic acid by Streptomyces clavuligerus is controlled the phosphate concentration. Phosphate represses biosynthesis “cephamycin synthetase”, expandase “clavulanic synthetase”. In presence 2 mM phosphate, specific activities expandase, synthetase” were higher than in 75 phosphate. The activity synthetase maximal with an initial concentration 10 mM, whereas 1 A correlation between was established at concentrations mM. This shows that important enzyme mechanism which affects cephamycin.
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Juan Francisco Martín, Control of antibiotic synthesis by phosphate Springer Berlin Heidelberg. pp. 105- 127 ,(1977) , 10.1007/3-540-08363-4_4
Shiro Nagai, Shunzo Inoue, Yoshinori Nishizawa, Stimulation of Streptomycin Formation by Streptomyces griseus Grown in a Phosphate Deficient Culture Journal of Fermentation Technology. ,vol. 60, pp. 417- 422 ,(1982)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Y. Aharonowitz, A. L. Demain, Carbon Catabolite Regulation of Cephalosporin Production in Streptomyces clavuligerus Antimicrobial Agents and Chemotherapy. ,vol. 14, pp. 159- 164 ,(1978) , 10.1128/AAC.14.2.159
Wei-Shou Hu, Alfredo F. Braña, Arnold L. Demain, Carbon source regulation of cephem antibiotic production by resting cells of Streptomyces clavuligerus and its reversal by protein synthesis inhibitors Enzyme and Microbial Technology. ,vol. 6, pp. 155- 160 ,(1984) , 10.1016/0141-0229(84)90023-1
A. G. BROWN, D. BUTTERWORTH, M. COLE, G. HANSCOMB, J. D. HOOD, C. READING, G. N. ROLINSON, Naturally-occurring .BETA.-lactamase inhibitors with antibacterial activity. The Journal of Antibiotics. ,vol. 29, pp. 668- 669 ,(1976) , 10.7164/ANTIBIOTICS.29.668
Claus L�bbe, Saul Wolfe, Arnold L. Demain, Repression and inhibition of cephalosporin synthetases in Streptomyces clavuligerus by inorganic phosphate Archives of Microbiology. ,vol. 140, pp. 317- 320 ,(1985) , 10.1007/BF00446970
M. Lever, Carbohydrate determination with 4-hydroxybenzoic acid hydrazide (PAHBAH): Effect of bismuth on the reaction Analytical Biochemistry. ,vol. 81, pp. 21- 27 ,(1977) , 10.1016/0003-2697(77)90594-2
Yair Aharonowitz, Arnold L. Demain, Influence of inorganic phosphate and organic buffers on cephalosporin production by Streptomyces clavuligerus Archives of Microbiology. ,vol. 115, pp. 169- 173 ,(1977) , 10.1007/BF00406371
J. Romero, P. Liras, J. F. Mart�n, Dissociation of cephamycin and clavulanic acid biosynthesis in Streptomyces clavuligerus Applied Microbiology and Biotechnology. ,vol. 20, pp. 318- 325 ,(1984) , 10.1007/BF00270593