Computational simulations of the total cavo-pulmonary connection: insights in optimizing numerical solutions

摘要: The Fontan procedure is a palliative surgical technique that used to treat patients with congenital heart defects include complex lesions such as those hypoplastic ventricle. In vitro, in vivo, and computational models of set modifications the procedure, called total cavopulmonary connection (TCPC), have been developed. Using these modeling methods, attempts made at finding most energy efficient TCPC circuit. Computational has distinct advantages other methods. However, discrepancies found validation studies models. There little literature available help explain correct for discrepancies. Differences results can occur when choosing between steady flow versus transient numerical solvers. this study solver were shown be more consistent from previous vitro experiments. we fluctuating patterns exist inflow boundary conditions TCPC. To date findings not reported literature. Furthermore, our suggest well magnitudes secondary structures diminish if offset vena cavae increased or flanged connections are added. An association was improvements circuit efficiencies. summary, development accurate simulations process critical efforts circuits, aimed potentially improving long term outcome patients.