Fatigue and Fatigability in Older Adults

摘要: Fatigue is believed to be a common complaint among older adults; however, multiple studies of self-reported fatigue across the lifespan have found this may not case. To explain paradox, article considers "fatigability"-a phenotype characterized by relationship between an individual's perceived and activity level with which associated. Fatigability measured combining self-report measures performance physical or cognitive activities, provided that work known can standardized. Doing so prevents self-pacing allows meaningful comparisons subjects studies. Increased fatigability aging arise from variety factors including age-related changes in energy production utilization, inflammatory mechanisms. A few published intervention targeted adults, though none examined specifically. Because represent physiologic warning system, future clinical benefit focus on fatigability, where both symptoms function are considered.