Perspectives on Fatigue from the Study of Chronic Fatigue Syndrome and Related Conditions

摘要: Fatigue is a symptom whose causes are protean and phenotype includes physical, mood, behavioral components. Chronic fatigue syndrome (CFS) an illness that has strong biological underpinnings no definite etiology. Diagnostic criteria established by the Centers for Disease Control Prevention have helped classify CFS as overlap of behavioral, These include presence more than 6 months associated with diminution functional activity somatic symptoms, pain not attributable to specific diagnosis or disease. Four following need be present: sore throat, impaired memory cognition, unrefreshing sleep, postexertional fatigue, tender glands, aching stiff muscles, joint pain, headaches. Many researchers observed shares features in common other syndromes, including irritable bowel syndrome, fibromyalgia, temporomandibular dysfunction. Correlations between inflammation infection, augmented sensory processing, abnormalities neurotransmitters, nerve growth factors, low levels serotonin norepinephrine, homeostasis stress system, autonomic dysfunction may hallmarks CFS. The relative contributions each these profound explored further better evaluate treat syndrome.