Microsatellite variation and the differentiation of modern humans.

摘要: This study presents an analysis of 20 tetranucleotide microsatellites in 16 worldwide human populations representing the major geographic groups. Global Fst values for are indicators their relative validity as tools population genetics. Four different measures genetic distance (Fst, DSW, δμ2 and Rst) have been tested compared with each other. Neighbor-joining trees constructed all populations. Measures such Fst, which does not consider mutational relationships among alleles has a known relationship to differentiation by drift, some extent reflect what is evolution, while mutation-based distances Rst give very results from those recognized other sources (genetic or archaeological). When between analyzed through allelic frequencies microsatellites, choice may be key issue picture obtained The present suggest that drift played main role generating distributions microsatellite variation populations; mutation must less important owing time constraint imposed small timescale most occurred. Moreover, support theory recent origin modern humans, although existence strong bottlenecks various groups seems unlikely.