Heterozygosities and allelic frequencies of a set of microsatellite markers used for genome-wide scans in a Chinese population
作者： E. Tan , H. Wu , R. Yong , S. Tan , J. Chang
关键词: Polymorphism (computer science) 、 Allele 、 Allele frequency 、 Genome 、 Loss of heterozygosity 、 Biology 、 Genetics 、 Population study 、 Microsatellite 、 Genetic marker
摘要: Microsatellite (short tandem repeat) markers are useful tools for genetic linkage analysis because of their high frequency occurrence in eukaryotic genomes, ease typing, and polymorphism content. To establish a panel microsatellite genome-wide screens the Chinese population, we determined heterozygosities allelic frequencies widely used set 285 208 individuals Han descent. Although median heterozygosity level our population was 0.72, only 63.6% these have at least 0.7, compared with 90.8% original Caucasian sample. The significant difference between populations suggests that should be optimally selected each study to maximize information content power.
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