Evaluation of a measles vaccine campaign by oral-fluid surveys in a rural Kenyan district: interpretation of antibody prevalence data using mixture models

作者: E. O. OHUMA , E. A. OKIRO , A. BETT , J. ABWAO , S. WERE

DOI: 10.1017/S0950268808000848

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摘要: We evaluated the effectiveness of a measles vaccine campaign in rural Kenya, based on oral-fluid surveys and mixture-modelling analysis. Specimens were collected from 886 children aged 9 months to 14 years pre-campaign comparison sample 598 6 post-campaign. Quantitative measles-specific antibody data obtained by commercial kit. The estimated proportions negative 0–4, 5–9 10–14 51%, 42% 27%, respectively, pre- 18%, 14% 6%, estimate reduction proportion susceptible 65–78%, with ~85% population recorded have received vaccine. ‘weak’ positive individuals rose 35% 54% Our results confirm reducing susceptibility demonstrate potential studies monitor impact vaccination campaigns.

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