Application of microsatellite markers for monitoring of reconstitution pattern in patients after bone marrow transplantation/peripheral blood progenitor cell transplantation.

摘要: We present data on application of microsatellite markers for detection complete vs. mixed chimerism in individuals after bone marrow transplantation (BMT) and peripheral blood progenitor cell (PBPCT). Genotypes the or cells three donor/recipient pairs were studied at several loci. In two cases we identified recipients' transplantation. These patients alive with no symptoms disease relapse and/or transplant rejection long time BMT PBPCT. third patient observed prevalence donor's genotype while she was well recipient's when relapsed required interferonotherapy. Results our molecular studies correlated patients' clinical outcome. show that may be used prediction