Contribution of the interventricular septum to maximal right ventricular function
作者： Uwe Klima , J. Luis Guerrero , Gus J. Vlahakes
DOI: 10.1016/S1010-7940(98)00179-1
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摘要: Objective: Maximal right ventricular (RV) function is influenced by left heart hemodynamics, possibly mediated the interventricular septum (IVS). We examined potential contribution of IVS to function. Methods: In 12 canine isovolumic preparations, incremental volumes were introduced into a high compliance RV balloon until failure occurred. developed pressure (RVDP) and maximal positive dP/dt determined with working at constant (LV) output 2 l/min mean arterial 80 mmHg. Thereafter was thermally inactivated, measurements repeated using same protocol. Results: At LV output, thermal inactivation led significant decrease in RVDP (inactivated vs. IVS: 36.1∠ 9.8 56.8 ∠ 16.2 mmHg, respectively, P , 0.001), 720 220 1350 190 mmHg/s, 0.001). Conclusions: These results suggest that functional status major determinant conditions pressure, an inactivated leads d P/dt under this study. © 1998 Elsevier Science B.V. All rights reserved
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G J Vlahakes, G T Hodakowski, W G Austen, W Harringer, J L Guerrero, P J LaRaia, R D Page, Determinants of maximal right ventricular function. Journal of Heart and Lung Transplantation. ,vol. 11, pp. 90- 98 ,(1992)
Donald Fa, Suter Pm, Romand Ja, Acute right ventricular failure, pathophysiology and treatment. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo. ,vol. 50, pp. 129- ,(1995)
W. L. Maughan, K. Sunagawa, K. Sagawa, Ventricular systolic interdependence: volume elastance model in isolated canine hearts. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 253, pp. 1381- 1389 ,(1987) , 10.1152/AJPHEART.1987.253.6.H1381
J E Calvin, Optimal right ventricular filling pressures and the role of pericardial constraint in right ventricular infarction in dogs. Circulation. ,vol. 84, pp. 852- 861 ,(1991) , 10.1161/01.CIR.84.2.852
K. S Li, W. P Santamore, Contribution of each wall to biventricular function Cardiovascular Research. ,vol. 27, pp. 792- 800 ,(1993) , 10.1093/CVR/27.5.792
Knut Auklndd, Fredrik Kiil, John Kjekshus, Relationship Between Ventricular Pressures and Right and Left Myocardial Blood Flow Acta Physiologica Scandinavica. ,vol. 70, pp. 116- 126 ,(1967) , 10.1111/J.1748-1716.1967.TB03606.X
J Ross, Acute displacement of the diastolic pressure-volume curve of the left ventricle: role of the pericardium and the right ventricle. Circulation. ,vol. 59, pp. 32- 37 ,(1979) , 10.1161/01.CIR.59.1.32
Sanjiv Kaul, The interventricular septum in health and disease American Heart Journal. ,vol. 112, pp. 568- 581 ,(1986) , 10.1016/0002-8703(86)90523-5
William P. Santamore, Louis J. Dell'Italia, Ventricular interdependence: Significant left ventricular contributions to right ventricular systolic function Progress in Cardiovascular Diseases. ,vol. 40, pp. 289- 308 ,(1998) , 10.1016/S0033-0620(98)80049-2
David E. Fixler, Joseph P. Archie, Daniel J. Ullyot, Gerald D. Buckberg, Julien I.E. Hoffman, Effects of acute right ventricular systolic hypertension on regional myocardial blood flow in anesthetized dogs. American Heart Journal. ,vol. 85, pp. 491- 500 ,(1973) , 10.1016/0002-8703(73)90493-6