Occupational exposures and mammographic density in Spanish women.

摘要: Objectives The association between occupational exposures and mammographic density (MD), a marker of breast cancer risk, has not been previously explored. Our objective was to investigate the influence exposure chemical, physical microbiological agents on MD in adult women. Methods This is population-based cross-sectional study based 1476 female workers aged 45–65 years from seven Spanish screening programmes. Occupational history surveyed by trained staff. Exposure assessed using job-exposure matrix MatEmESp. Percentage measured two radiologists semiautomatic computer tool. estimated mixed log-linear regression models adjusting for age, education, body mass index, menopausal status, parity, smoking, alcohol intake, type mammography, family hormonal therapy use, including centre professional reader as random effects terms. Results Although no found with most agents, women occupationally exposed perchloroethylene (e β =1.51; 95% CI 1.04 to 2.19), ionising radiation =1.23; 0.99 to 1.52) mould spores =1.44; 1.01 to 2.04) tended have higher MD. percentage increased 12% every 5 years or spores, 11% aliphatic/alicyclic hydrocarbon solvents 3% each radiation. Conclusions perchloroethylene, radiation, settings could be associated Further studies are needed clarify accuracy reasons these findings.