Adenylylcyclase Increases Responsiveness to Catecholamine Stimulation in Transgenic Mice

摘要: Background—The cellular content of cAMP generated by activation adenylylcyclase (AC) through the β-adrenergic receptor (βAR) is a key determinant cell’s response to catecholamine stimulation. We tested hypothesis that increased AC content, independently βAR number, increases responsiveness stimulation in vivo. Methods and Results—Transgenic mice with cardiac-directed expression ACVI showed transgene but no change myocardial number or G-protein content. When stimulated βAR, cardiac function was increased, myocytes production. In contrast, basal were normal, long-term not associated abnormal histological findings deleterious changes function. Conclusions—The amount sets limit on signaling vivo, AC, independent provides means regulate card...