Evidence for a calcification process in the trabecular meshwork.

摘要: Abstract The human trabecular meshwork (TM) expresses many genes that have been associated with physiological (bone, cartilage, teeth) and pathological (vascular systems, kidney) calcification. In particular, the TM highly inhibitor of calcification Matrix Gla (MGP) gene, which encodes a vitamin K-dependent protein requires post-translational activation to inhibit formation calcium precipitates. cells high activity activating γ-carboxylase enzyme produce active MGP. Silencing MGP increases alkaline phosphatase (ALP), an matrix vesicles marker Overexpressing reduces ALP induced by bone morphogenetic 2 (BMP2), potent inducer this review we gathered evidence for existence mineralization process in TM. We selected twenty regulatory genes, reviewed their functions original tissues looked at relative abundance heat maps derived from existing microarrays. Although results are not yet fully conclusive more experiments needed, examining expression light literature brings up similarities. One such parallel is role mechanical forces induction levels inhibitors found constantly mechanically stressed During next few years, examination other calcification-related pathways, as well morphological knockout animals, would help elucidate relevance TM's overall function.