Iron metabolic disorder in chronic hepatitis C: mechanisms and relevance to hepatocarcinogenesis.

摘要: The liver is the major iron storage organ in body, and therefore, metabolic disorder sometimes involved chronic diseases. Chronic hepatitis C one of diseases that show hepatic accumulation, even though its level should be recognized to basically mild moderate within normal range. mechanisms underlying accumulation have not been fully elucidated. Reduction hepcidin transcription activity by virus (HCV)-induced reactive oxygen species may part account for it, but regulation very complex depend on many variables, including particular stage systemic and/or inflammatory conditions circulating transferrin-bound intracellular stores. This might explain variations concentrations reported among patients with HCV-related disease. However, mild-to-moderate overload contributes disease progression hepatocarcinogenesis probably reinforcing HCV-induced oxidative stress through Fenton reaction. present review highlights current concept status discusses how develops this impact relevance hepatocarcinogenesis.