The role of fluorodeoxyglucose, 18F-dihydroxyphenylalanine, 18F-choline, and 18F-fluoride in bone imaging with emphasis on prostate and breast.

摘要: Diagnostic imaging has played a major role in the evaluation of patients with bone metastases. The modalities have included scintigraphy, computed tomography, magnetic resonance imaging, and most recently PET/CT, which can be performed different tracers, including fluorodeoxyglucose (FDG), 18F-fluoride, 18F-choline (FCH), 18F-DOPA (dihydroxyphenylalanine). For tumors sensitivity FDG detecting metastases is similar to scintigraphy; additionally it used monitor response chemotherapy hormonal therapy. 18F-Fluoride may provide more sensitive "conventional" scan superior for nonavid tumors, but, nevertheless, "early disease" often clear advantages over 18F-fluoride. Although data need obtained, appears that FCH highly efficient preoperative management regarding N M staging prostate cancer once metastatic disease strongly suspected or documented. neuroendocrine particular medullary thyroid cancer, DOPA 18F-fluoride providing high quality information skeleton. Nevertheless, prospective studies large patient groups will essential define exact diagnostic PET clinical settings.