Research Note: Evaluation of deoxycholic acid for antihistomonal activity

摘要: Abstract Deoxycholic acid (DCA) is a naturally occurring secondary bile that originates from intestinal bacterial metabolic conversion of cholate, primary acid. was shown to have antihistomonal properties in vitro, leading our hypothesis DCA inclusion within the feed might prevent histomoniasis. Selected dietary concentrations were evaluated for effects on body weight gain (BWG), lesions, and mortality turkeys challenged with wild-type Histomonas meleagridis (WTH). Treatments consisted non-challenged control (NC; basal diet), 0.25% diet + challenge, 0.5% 1% positive-challenged (PC; diet). All groups fed starter diet until day 7, at which time diets administered respective groups. On 14, 2 × 105 WTH cells/turkey intracloacally administered. H. meleagridis-related lesions 13 post-challenge. Pre-challenge 0 14 BWG higher (P ≤ 0.05) in group than group. There no significant differences pre-challenge between any other No mortalities histomoniasis occurred as compared PC or observed NC Presence liver Using same controls experimental timeline, an additional included evaluate biliogenic formulated 20% whole egg powder encourage endogenous production. The had statistical impact BWG, but did not reduce after challenge. Taken together, these data suggest under conditions does