Experimental regional cerebral ischemia in the middle cerebral artery territory in primates. Part 1: Angio-anatomy and description of an experimental model with selective embolization of the internal carotid artery bifurcation.

摘要: Selective embolization of the internal carotid artery bifurcation (ICA bifurcation) was performed in monkeys (Macaca mulatta) to study acute regional cerebral ischemia middle (MCA) territory with minimum surgical intervention neck under sedated conditions. The anthropomorphic similarity angio-anatomy system and use silastic spheres, as artificial emboli, critical diameter 1.2 1.4 mm resulted overall success rate 87% localizing site ICA bifurcation, producing whole territory. All animals ICA-bifurcation had contralateral deep motor weakness conjugate eye deviation nystagmus toward embolization. Simultaneous EEG recording showed flattening basic background activities over affected MCA area arteriograms definite retrograde filling proximally occluded MCA. Clinical recovery observed a few within two five hours Gross ischemic swelling territory, particularly gray matter, became obvious six eight which were exposed four ischemia. angio-anatomical this experimental animal for stroke model confirmed previous observations other investigators that extremely abundant leptomeningeal anastomoses would be one major factors leading variability clinicopathological pictures seen models proximal occlusion. In addition, pre-parenchymal base brain between medial striate arteries from anterior (ACA) lateral lenticulostriate described possible functional collateral basal ganglia case