Aqueous Extract of Phyllanthus urinaria Induces Apoptosis in Human Cancer Cells
作者： Sheng-Teng Huang , Rong-Chi Yang , Jong-Hwei S. Pang
DOI: 10.1142/S0192415X04001849
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摘要: Cell apoptosis is now known to play an important role in the maintenance of cellular homeostasis and anti-carcinogenesis. The anticancer effect aqueous extract prepared from Phyllanthus urinaria (P. urinaria) was investigated by analyzing its potential induce human cancer cells. We showed that P. could reduce viability inducing cells derived several different origins as demonstrated morphological changes DNA fragmentation. Yet, exhibited no cytotoxic on normal cells, including vascular endothelial liver under same conditions. It suggests substantially useful treating various kinds without toxic side
sci-hub.se 参考文章(23)
Veronique Mansat, Ali Bettaïeb, Thierry Levade, Guy Laurent, Jean‐Pierre Jaffrézou, Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin. The FASEB Journal. ,vol. 11, pp. 695- 702 ,(1997) , 10.1096/FASEBJ.11.8.9240970
Hartwig Wolburg, Wolfgang Wick, Gesa Rascher, Mathias Bähr, Ulrike Naumann, Emmanuel Conseiller, Michael Weller, Sebastian Kügler, Jörg B. Schulz, Chimeric tumor suppressor 1, a p53-derived chimeric tumor suppressor gene, kills p53 mutant and p53 wild-type glioma cells in synergy with irradiation and CD95 ligand. Cancer Research. ,vol. 61, pp. 5833- 5842 ,(2001)
Garth Powis, David J. Moore, High-performance liquid chromatographic assay for the antitumor glycoside phyllanthoside and its stability in plasma of several species. Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 342, pp. 129- 134 ,(1985) , 10.1016/S0378-4347(00)84495-3
Lee Jamieson, Lee Carpenter, Trevor J. Biden, Alan P. Fields, Protein Kinase Cι Activity Is Necessary for Bcr-Abl-mediated Resistance to Drug-induced Apoptosis Journal of Biological Chemistry. ,vol. 274, pp. 3927- 3930 ,(1999) , 10.1074/JBC.274.7.3927
Yu-Hong Du, Paul Ho, Arsenic compounds induce cytotoxicity and apoptosis in cisplatin-sensitive and -resistant gynecological cancer cell lines. Cancer Chemotherapy and Pharmacology. ,vol. 47, pp. 481- 490 ,(2001) , 10.1007/S002800100278
Tatsuya Matsura, Masachika Kai, Yasuyoshi Fujii, Hisao Ito, Kazuo Yamada, Hydrogen peroxide-induced apoptosis in HL-60 cells requires caspase-3 activation Free Radical Research. ,vol. 30, pp. 73- 83 ,(1999) , 10.1080/10715769900300081
Hanping Feng, Yi Zeng, Luke Whitesell, Emmanuel Katsanis, Stressed apoptotic tumor cells express heat shock proteins and elicit tumor-specific immunity Blood. ,vol. 97, pp. 3505- 3512 ,(2001) , 10.1182/BLOOD.V97.11.3505
Angel Sànchez-Lamar, Mario Fiore, Enrico Cundari, Ruggero Ricordy, Renata Cozzi, Rosella De Salvia, Phyllanthus orbicularis Aqueous Extract: Cytotoxic, Genotoxic, and Antimutagenic Effects in the CHO Cell Line Toxicology and Applied Pharmacology. ,vol. 161, pp. 231- 239 ,(1999) , 10.1006/TAAP.1999.8814
O. Ishiko, T. Sumi, H. Yoshida, S. Ogita, R. Yamada, Expression of apoptosis regulatory proteins in advanced cancer of the uterine cervix after cyclic balloon-occluded arterial infusion chemotherapy. International Journal of Oncology. ,vol. 18, pp. 1151- 1155 ,(2001) , 10.3892/IJO.18.6.1151
Won-Gil Seo, Hyun-Ock Pae, Gi-Su Oh, Kyu-Yun Chai, Young-Gab Yun, Hun-Taeg Chung, Kyu Kwan Jang, Tae-Oh Kwon, Ethyl acetate extract of the stem bark of Cudrania tricuspidata induces apoptosis in human leukemia HL-60 cells. The American Journal of Chinese Medicine. ,vol. 29, pp. 313- 320 ,(2001) , 10.1142/S0192415X01000332