Analysis of the in vivo proliferative capacity of a whole cell cancer vaccine.

摘要: A polyvalent therapeutic cancer cell vaccine containing three viable, irradiated, replication-incompetent melanoma lines (Canvaxin) was administered to over 2500 patients in various clinical studies. This study examines the fate of Canvaxin cells 16 with Stage II, III or IV melanoma, special attention on assessing capacity replicate. The survival time and potential proliferative irradiated humans studied by histologic examination biopsies injection sites a two-week period. overall results show that mitotic index skin (0.12%) approximately 6 times lower than control value (0.71%). Similarly, there an trend toward decrease figures during two week observation periods. Also, towards number increasing cycles. data indicate do not proliferate after intra-dermal injection, typically associated immune response are present at inoculation sites.