IGF-1 and IGFBP-3: Risk of prostate cancer among men in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.
作者： Jocelyn M. Weiss , Wen-Yi Huang , Sabina Rinaldi , Thomas R. Fears , Nilanjan Chatterjee
DOI: 10.1002/IJC.22921
关键词:
摘要: IGF-1 and IGFBP-3 may influence risk of prostate cancer through their roles in cellular growth, metabolism apoptosis, however, epidemiologic results have been inconsistent. The role obesity is not clearly understood, but hyperinsulinemia-related increases bioactive levels, associated with obesity, could be a component the relationship between IGF-axis cancer. We conducted nested case-control study prospective Prostate, Lung, Colorectal Ovarian Cancer Screening Trial to examine associations A total 727 incident cases 887 matched controls were selected for this analysis. There was no clear overall association IGF-1, IGF-1:IGFBP-3 molar ratio (IGFmr) risk, IGFmr obese men (BMI > 30, p-trend = 0.04), greater than 2-fold increased highest quartile (OR 2.34, 95% CI 1.10-5.01). Risk specifically aggressive disease 2.80, 1.11-7.08). In summary, our large showed insulin-like growth factor axis related men.
elsevier.com
sci-hub.se 参考文章(69)
Li Li, Herbert Yu, Fredrick Schumacher, Graham Casey, John S Witte, None, Relation of serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 to risk of prostate cancer (United States). Cancer Causes & Control. ,vol. 14, pp. 721- 726 ,(2003) , 10.1023/A:1026383824791
JEAN-PAUL THISSEN, JEAN-MARIE KETELSLEGERS, LOUIS E. UNDERWOOD, Nutritional Regulation of the Insulin-Like Growth Factors* Endocrine Reviews. ,vol. 15, pp. 80- 101 ,(1994) , 10.1210/EDRV-15-1-80
Libby M. Morimoto, Polly A. Newcomb, Emily White, Jeannette Bigler, John D Potter, Variation in Plasma Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3: Personal and Lifestyle Factors (United States) Cancer Causes & Control. ,vol. 16, pp. 917- 927 ,(2005) , 10.1007/S10552-005-2702-3
Al Baha Barqawi, Brian K. Golden, Colin O’Donnell, Michael K. Brawer, E. David Crawford, Observed effect of age and body mass index on total and complexed PSA: Analysis from a national screening program Urology. ,vol. 65, pp. 708- 712 ,(2005) , 10.1016/J.UROLOGY.2004.10.074
M. Terzolo, C. Matrella, A. Boccuzzi, S. Luceri, M. Borriero, G. Reimondo, A. Pia, E. Rovero, P. Paccotti, A. Angeli, Twenty-four hour profile of blood pressure in patients with acromegaly. Correlation with demographic, clinical and hormonal features. Journal of Endocrinological Investigation. ,vol. 22, pp. 48- 54 ,(1999) , 10.1007/BF03345478
Eugenia E. Calle, Rudolf Kaaks, Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms Nature Reviews Cancer. ,vol. 4, pp. 579- 591 ,(2004) , 10.1038/NRC1408
SY Nam, EJ Lee, KR Kim, BS Cha, YD Song, SK Lim, HC Lee, KB Huh, Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone International Journal of Obesity. ,vol. 21, pp. 355- 359 ,(1997) , 10.1038/SJ.IJO.0800412
Geraldine Cancel-Tassin, Olivier Cussenot, Genetic susceptibility to prostate cancer BJUI. ,vol. 96, pp. 1380- 1385 ,(2005) , 10.1111/J.1464-410X.2005.05836.X
Renato Baserga, Francesca Peruzzi, Krysztof Reiss, The IGF-1 receptor in cancer biology. International Journal of Cancer. ,vol. 107, pp. 873- 877 ,(2003) , 10.1002/IJC.11487
Jacques Baillargeon, Brad H. Pollock, Alan R. Kristal, Patrick Bradshaw, Javier Hernandez, Joseph Basler, Betsy Higgins, Steve Lynch, Thomas Rozanski, Dean Troyer, Ian Thompson, The association of body mass index and prostate-specific antigen in a population-based study. Cancer. ,vol. 103, pp. 1092- 1095 ,(2005) , 10.1002/CNCR.20856