Phenotypes and genotypes of insulin-like growth factor 1, IGF-binding protein-3 and cancer risk: evidence from 96 studies.
作者： Wensen Chen , Sumin Wang , Tian Tian , Jianling Bai , Zhibin Hu
DOI: 10.1038/EJHG.2009.86
关键词:
摘要: Insulin-like growth factor 1 (IGF1) and its main binding protein, IGF-binding protein 3 (IGFBP3), play an important role in cancer development. Circulating levels functional polymorphisms of IGF1 IGFBP3 may be biomarkers However, the results published studies remain conflicting rather than conclusive. We searched MEDLINE EMBASE databases for all related to circulating risk. In all, 96 over 110 000 subjects were available this meta-analysis. Higher significantly increased 15% risk (odds ratio (OR), 1.15, 95% confidence interval (CI), 1.03–1.29), especially among prostate, pre-menopausal breast colorectal patients, whereas higher concentrations decreased advanced prostate by 56% (OR, 0.44, CI, 0.25–0.77). Meanwhile, −202CC genotype was associated with borderline significance 1.18, 0.99–1.41). Genotype–phenotype correlation analyses showed that could modified promoter polymorphism A−202C (P < 0.001). conclusion, IGF1, a crucial carcinogenesis serve as susceptibility
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Li Li, Herbert Yu, Fredrick Schumacher, Graham Casey, John S Witte, None, Relation of serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 to risk of prostate cancer (United States). Cancer Causes & Control. ,vol. 14, pp. 721- 726 ,(2003) , 10.1023/A:1026383824791
Douglas Yee, Adrian V. Lee, Crosstalk between the insulin-like growth factors and estrogens in breast cancer. Journal of Mammary Gland Biology and Neoplasia. ,vol. 5, pp. 107- 115 ,(2000) , 10.1023/A:1009575518338
Hyi-Jeong Tae, Xiaochun Luo, Ki-Han Kim, Roles of CCAAT/enhancer-binding protein and its binding site on repression and derepression of acetyl-CoA carboxylase gene. Journal of Biological Chemistry. ,vol. 269, pp. 10475- 10484 ,(1994) , 10.1016/S0021-9258(17)34084-X
Edward Giovannucci, Insulin, Insulin-Like Growth Factors and Colon Cancer: A Review of the Evidence Journal of Nutrition. ,vol. 131, ,(2001) , 10.1093/JN/131.11.3109S
Eva S. Schernhammer, Susan E. Hankinson, David J. Hunter, Marie J. Blouin, Michael N. Pollak, Polymorphic variation at the -202 locus in IGFBP3: Influence on serum levels of insulin-like growth factors, interaction with plasma retinol and vitamin D and breast cancer risk. International Journal of Cancer. ,vol. 107, pp. 60- 64 ,(2003) , 10.1002/IJC.11358
K DeLellis, S Ingles, L Kolonel, R McKean-Cowdin, B Henderson, F Stanczyk, N M Probst-Hensch, IGF1 genotype, mean plasma level and breast cancer risk in the Hawaii/Los Angeles multiethnic cohort British Journal of Cancer. ,vol. 88, pp. 277- 282 ,(2003) , 10.1038/SJ.BJC.6600728
Angela Cox, Alison M Dunning, Montserrat Garcia-Closas, Sabapathy Balasubramanian, Malcolm WR Reed, Karen A Pooley, Serena Scollen, Caroline Baynes, Bruce AJ Ponder, Stephen Chanock, Jolanta Lissowska, Louise Brinton, Beata Peplonska, Melissa C Southey, John L Hopper, Margaret RE McCredie, Graham G Giles, Olivia Fletcher, Nichola Johnson, Isabel dos Santos Silva, Lorna Gibson, Stig E Bojesen, Børge G Nordestgaard, Christen K Axelsson, Diana Torres, Ute Hamann, Christina Justenhoven, Hiltrud Brauch, Jenny Chang-Claude, Silke Kropp, Angela Risch, Shan Wang-Gohrke, Peter Schürmann, Natalia Bogdanova, Thilo Dörk, Rainer Fagerholm, Kirsimari Aaltonen, Carl Blomqvist, Heli Nevanlinna, Sheila Seal, Anthony Renwick, Michael R Stratton, Nazneen Rahman, Suleeporn Sangrajrang, David Hughes, Fabrice Odefrey, Paul Brennan, Amanda B Spurdle, Georgia Chenevix-Trench, Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer, Jonathan Beesley, Arto Mannermaa, Jaana Hartikainen, Vesa Kataja, Veli-Matti Kosma, Fergus J Couch, Janet E Olson, Ellen L Goode, Annegien Broeks, Marjanka K Schmidt, Frans BL Hogervorst, Laura J Van't Veer, Daehee Kang, Keun-Young Yoo, Dong-Young Noh, Sei-Hyun Ahn, Sara Wedrén, Per Hall, Yen-Ling Low, Jianjun Liu, Roger L Milne, Gloria Ribas, Anna Gonzalez-Neira, Javier Benitez, Alice J Sigurdson, Denise L Stredrick, Bruce H Alexander, Jeffery P Struewing, Paul DP Pharoah, Douglas F Easton, Breast Cancer Association Consortium, None, A common coding variant in CASP8 is associated with breast cancer risk Nature Genetics. ,vol. 39, pp. 352- 358 ,(2007) , 10.1038/NG1981
J L Martin, J A Coverley, S T Pattison, R C Baxter, Insulin-like growth factor-binding protein-3 production by MCF-7 breast cancer cells: stimulation by retinoic acid and cyclic adenosine monophosphate and differential effects of estradiol. Endocrinology. ,vol. 136, pp. 1219- 1226 ,(1995) , 10.1210/ENDO.136.3.7532580
Catherine McCaig, Claire M Perks, Jeff MP Holly, Intrinsic actions of IGFBP-3 and IGFBP-5 on Hs578T breast cancer epithelial cells: inhibition or accentuation of attachment and survival is dependent upon the presence of fibronectin. Journal of Cell Science. ,vol. 115, pp. 4293- 4303 ,(2002) , 10.1242/JCS.00097
Jocelyn M. Weiss, Wen-Yi Huang, Sabina Rinaldi, Thomas R. Fears, Nilanjan Chatterjee, David Chia, E. David Crawford, Rudolf Kaaks, Richard B. Hayes, IGF-1 and IGFBP-3: Risk of prostate cancer among men in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. International Journal of Cancer. ,vol. 121, pp. 2267- 2273 ,(2007) , 10.1002/IJC.22921