Effector T cell plasticity: flexibility in the face of changing circumstances
作者： Kenneth M Murphy , Brigitta Stockinger
DOI: 10.1038/NI.1899
关键词:
摘要: As more states of CD4 T cell differentiation are uncovered, their flexibility is also beginning to be recognized. Components that control the plasticity populations include cellular conditions, clonality, transcriptional circuitry and chromatin modifications. Appearance may arise from truly flexible genetic programs or, alternatively, heterogeneous populations. New tools will needed define rules allow or prohibit transitions.
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