摘要: Abstract : This purpose of this proposal is to use high resolution microPET technology image ovarian cancer integrin expression in vivo. Ovarian angiogenesis dependent. Integrin , a key player tumor and metastasis, has been identified as target for diagnostic therapeutic interventions several highly proliferative metastatic types. The interaction between vitronectin alphanuBeta3 essential cell survival invasion. marker poor prognosis advanced-stage cancer. Its role development treatment under-developed. Specific Aim 1: To develop optimize 18F-labeled RGD peptides carcinoma targeting. 2: test 18F-RGD peptide tracers models different levels order correlate the magnitude uptake with receptor density. Major Findings: In year 1, we have synthesized series multimeric alphavbeta3 affinity/specificity labeled these F-18 PET imaging vivo (Aim 1). We also established differentiated 2). Further optimal radiotracer tracer currently underway
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