作者: Glenn A. Burley , Johannes Gierlich , Mohammad R. Mofid , Hadar Nir , Shay Tal
DOI: 10.1021/JA055517V
关键词: Aldehyde 、 Chemistry 、 Stereochemistry 、 Chemical modification 、 Tollens' reagent 、 Click chemistry 、 DNA 、 Gene 、 Combinatorial chemistry
摘要: Genes of interest can be selectively metallized via the incorporation modified triphosphates. These triphosphates bear functions that further derivatized with aldehyde groups use click chemistry. Treatment aldehyde-labeled gene mixture Tollens reagent, followed by a development process, results in selective metallization presence natural DNA strands.