Directed DNA Metallization

作者: Glenn A. Burley , Johannes Gierlich , Mohammad R. Mofid , Hadar Nir , Shay Tal

DOI: 10.1021/JA055517V

关键词: AldehydeChemistryStereochemistryChemical modificationTollens' reagentClick chemistryDNAGeneCombinatorial chemistry

摘要: Genes of interest can be selectively metallized via the incorporation modified triphosphates. These triphosphates bear functions that further derivatized with aldehyde groups use click chemistry. Treatment aldehyde-labeled gene mixture Tollens reagent, followed by a development process, results in selective metallization presence natural DNA strands.

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