Clinical markers of Crohn's disease severity and their association with opiate use.

摘要: Background: The safety of opiate use for patients with Crohn’s disease (CD) has long been a concern. recent therapy, resource, evaluation, and assessment tool (TREAT) registry update added to these concerns by demonstrating an association increased risk infection death in CD. While the is clear, relationship opiates negative outcomes not. It unknown whether are contributing factor or if their merely marker more severe disease. We hypothesized that not harmful CD but severity would be associated commonly accepted clinical markers such as early age at onset, duration, small intestinal involvement, history fistula stricture, lower quality life (QOL) scores. Methods: Data on including pain medication usage were obtained from interviewer directed survey admitted two tertiary care hospitals over 2-year period. primary admitting diagnosis was required. Active defined within past month prior admission. Results: A total 133 approached participate, whom 108 consented survey, 51 active users. Opiate using smokers (22% vs. 3.45%, P < 0.010), had fistulas (40% 22.4%, 0.048) poorer score short form inflammatory bowel questionnaire (mean 3.80 4.34, 0.036) than non-opiate No difference found between users non-users diagnosis, strictures. Conclusions: study findings demonstrate fistulas, smoking, QOL suggest may directly CD, another severity. However, given unproven benefits term control dependence, caution should still exercised use. J Clin Med Res. 2015;7(1):33-36 doi: http://dx.doi.org/10.14740/jocmr1969w