Apparent diffusion coefficient and fractional anisotropy of newly diagnosed grade II gliomas.

摘要: Distinguishing between low-grade oligodendrogliomas (ODs) and astrocytomas (AC) is of interest for defining prognosis stratifying patients to specific treatment regimens. The purpose this study was determine if the apparent diffusion coefficient (ADC) fractional anisotropy (FA) from imaging can help differentiate newly diagnosed grade II OD AC subtypes evaluate ADC FA values mixed population oligoastrocytomas (OA). Fifty-three with gliomas were studied using a 1.5T whole body scanner (23 ODs, 16 ACs, 14 OAs). protocol included post-gadolinium T1-weighted images, T2-weighted either three and/or six directional sequence b = 1000 s/mm2. Diffusion-weighted images analyzed in-house software calculate maps acquisitions, FA. intensity normalized by normal appearing white matter (NAWM) generate (nADC) (nFA). hyperintense region in T2 weighted image defined as T2All region. A Mann–Whitney rank-sum test performed on 25th, median, 75th nADC nFA among subtypes. Logistic regression how well predict subtype. Lesions being had significantly lower higher nFA, compared AC. individually classified data an accuracy 87%. Combining two did not enhance classification. OA those This suggests that may be helpful directing tissue sampling most appropriate regions taking biopsies order make definitive diagnosis. Copyright © 2008 John Wiley & Sons, Ltd.