Transcription of the SCL/TAL1 Interrupting Locus (Stil) Is Required for Cell Proliferation in Adult Zebrafish Retinas
作者： Lei Sun , Ping Li , Aprell L. Carr , Ryne Gorsuch , Clare Yarka
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摘要: The human oncogene SCL/TAL1 interrupting locus (Stil) is highly conserved in vertebrate species. Previously, we identified a homolog of the Stil gene zebrafish mutant (night blindness b, nbb), which showed neural defects retina (e.g. dopaminergic cell degeneration and/or lack regeneration). In this research, examined roles proliferation after adult retinas. We demonstrated that knockdown expression or inhibition Sonic hedgehog (Shh) signaling transduction decreases rate proliferation. contrast, activation Shh signal promotes nbb+/− retinas, SUFU (a repressor pathway) rescues due to down-regulation expression. latter data suggest play role through pathway.
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