Mitochondrial aconitase knockdown attenuates paraquat‐induced dopaminergic cell death via decreased cellular metabolism and release of iron and H2O2
作者： David Cantu , Ruth E. Fulton , Derek A. Drechsel , Manisha Patel
DOI: 10.1111/J.1471-4159.2011.07290.X
关键词:
摘要: … To determine the role of neuronal m-aconitase as a source of H 2 O 2 and Fe 2+ , we asked whether oxidative inactivation of m-aconitase resulted in accumulation of H 2 O 2 , Fe 2+ and …
sci-hub.se 参考文章(66)
Paul R. Gardner, Superoxide-Driven Aconitase FE-S Center Cycling Bioscience Reports. ,vol. 17, pp. 33- 42 ,(1997) , 10.1023/A:1027383100936
Ildiko Sipos, Laszlo Tretter, Vera Adam‐Vizi, The production of reactive oxygen species in intact isolated nerve terminals is independent of the mitochondrial membrane potential Neurochemical Research. ,vol. 28, pp. 1575- 1581 ,(2003) , 10.1023/A:1025634728227
J. John Holbrook, Anders Liljas, Steven J. Steindel, Michael G. Rossmann, 4 Lactate Dehydrogenase The Enzymes. ,vol. 11, pp. 191- 292 ,(1975) , 10.1016/S1874-6047(08)60212-7
James D. Crapo, Robert D. Pearlstein, David S. Warner, G. Burkhard Mackensen, Manisha Patel, Huaxin Sheng, Carla L. Calvi, Ines Batinić-Haberle, Brian J. Day, Li Ping Liang, Irwin Fridovich, Neuroprotection from Delayed Postischemic Administration of a Metalloporphyrin Catalytic Antioxidant The Journal of Neuroscience. ,vol. 21, pp. 4582- 4592 ,(2001) , 10.1523/JNEUROSCI.21-13-04582.2001
P.R. Gardner, I. Fridovich, Superoxide sensitivity of the Escherichia coli aconitase. Journal of Biological Chemistry. ,vol. 266, pp. 19328- 19333 ,(1991) , 10.1016/S0021-9258(18)55001-8
J A Imlay, I Fridovich, Assay of metabolic superoxide production in Escherichia coli Journal of Biological Chemistry. ,vol. 266, pp. 6957- 6965 ,(1991) , 10.1016/S0021-9258(20)89596-9
Qing-You Li, Cynthia Pedersen, Brian J. Day, Manisha Patel, Dependence of excitotoxic neurodegeneration on mitochondrial aconitase inactivation Journal of Neurochemistry. ,vol. 78, pp. 746- 755 ,(2001) , 10.1046/J.1471-4159.2001.00457.X
D.H. Flint, J.F. Tuminello, M.H. Emptage, The inactivation of Fe-S cluster containing hydro-lyases by superoxide. Journal of Biological Chemistry. ,vol. 268, pp. 22369- 22376 ,(1993) , 10.1016/S0021-9258(18)41538-4
P.R. Gardner, I Fridovich, Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical. Journal of Biological Chemistry. ,vol. 267, pp. 8757- 8763 ,(1992) , 10.1016/S0021-9258(19)50343-X
P R Gardner, I Fridovich, Superoxide sensitivity of the Escherichia coli 6-phosphogluconate dehydratase. Journal of Biological Chemistry. ,vol. 266, pp. 1478- 1483 ,(1991) , 10.1016/S0021-9258(18)52319-X