Amide proton transfer imaging of 9L gliosarcoma and human glioblastoma xenografts.

摘要: Amide proton transfer (APT) imaging is a variant of magnetization (MT) imaging, in which the contrast determined by change water intensity due to chemical exchange with saturated amide protons endogenous mobile proteins and peptides. In this study, eight Fisher 344 rats implanted 9L gliosarcoma cells six nude human glioblastoma were imaged at 4.7 T. There increased signal intensities tumors APT-weighted images. The APT between tumor contralateral brain tissue was about 3.9% (1.49% ± 0.66% versus −2.36% 0.19%) for more uniformly hypercellular tumors, it reduced 1.6% (−1.18% 0.60% −2.77% 0.42%) xenografts that contained hypocellular zones necrosis. preliminary results show technique protein level may provide unique MRI characterization tumors.