Frequency of pre-existing actinic keratosis in cutaneous squamous cell carcinoma.

摘要: Background Controversy over the rate of malignant transformation actinic keratosis (AK) into cutaneous squamous cell carcinoma (SCC) has generated considerable debate regarding importance treating all such precancers to preclude their transofrmation. Current changes in US healthcare policy will deny many individuals access certain simple and effective treatment modalities for precancerous lesions. Objective Our purpose was determine whether there is a significant association between presence SCC pre-existing AK. Methods One hundred sixty five consecutive cases SCC, retrieved from files university-affiliated dermatopathology laboratory serving north-central Florida, were selected review by single dermatopathologist (D.M.). Hematoxylin eosin stained skin tissue slides examined under light microscopy AK close proximity to, or giving rise SCC. Results Of 165 reviewed, 82.4% (136 out 165) found have concomitant and/or SCC. 136 AK-positive cases, 26.7% (44) identified as superficial arising within an (AKSSCC) 55.7% (92) had (AK + SCC). Close defined include located directly adjacent (on shoulder of) maximum distance 8 mm away. Conclusions The prevalence our biopsy population suggests strong correlation these two lesions. fact that lesions highlights early recognition AK.