Biobased Cryogels from Enzymatically Oxidized Starch: Functionalized Materials as Carriers of Active Molecules.

摘要: Starch recovered from an agrifood waste, pea pods, was enzymatically modified and used to prepare cryogels applied as drug carriers. The enzymatic modification of starch performed using the laccase/(2,2,6,6-tetramethylpiperidin-1-yl)oxyl TEMPO system, at a variable molar ratio. characterization ensuing starches by solution NMR spectroscopy showed partial conversion primary hydroxyl groups versus aldehyde carboxyl successive creation hemiacetal ester bonds. Enzymatically after simple freezing lyophilization process provided stable compact with morphology characterized irregular pores, determined atomic force (AFM) scanning electron microscopy (SEM). application carriers active molecules successfully evaluated following two different approaches loading drugs: a) loaded sponge, adsorption liquid phase; b) dry-loaded cryogel, dehydration step added cryogel route (a). efficiency routes studied compared determining release profile proton studies over time. Preliminary results demonstrated that are good candidates act delivery systems due their stability prolonged residence times molecules, opening promising applications in biomedical food packaging scenarios.