Deposition of advanced glycation end products (AGE) and expression of the receptor for AGE in cardiovascular tissue of the diabetic rat.

摘要: Advanced glycation end products (AGE) in tissues are important for the central pathological features of diabetic complication. Although AGE bind to several cell-surface sites, resulting altered cellular functions, receptor (RAGE) appears have a role. We examined accumulation and RAGE expression aorta heart rats with streptozotocin (STZ)-induced diabetes, 0, 4, 8, 12, 16 24 weeks after STZ administration. Early atherosclerotic findings intima medial thinning were observed STZ-Induced diabetes. Immunohistochemistry microscope spectrophotometry showed that deposition increased significantly vessels myocardium, depending on period hyperglycaemia. was expressed endothelial cells vascular smooth muscle all animals. The number immunoreactivity until 12 injection, then decreased diabetes between weeks. On other hand, total mRNA levels continued increase duration Furthermore, AGE-BSA induced human umbilical vein vitro. Taken together, might initiate macroangiopathy through RAGE, by could be reason mellitus accelerates atherosclerosis rapidly.