Treatment of the Prostate in the Presence of Metastases: Lessons from Other Solid Tumors

摘要: [1_TD$DIFF]Any intelligent oncologist will readily admit that the mainstay of curative treatment for virtually all solid tumors when they are not metastatic is surgery. With a few exceptions, medical and radiation oncologists generally provide adjunctive treatments to improve local control or cure rates—not unimportant functions but still central roles in cancer patient. In contrast, patients present with disease recurrenceoccursandcure isno longerpossible, surgeons pass patient along have limited management thereafter. Except which randomized trials demonstrated survival benefits surgery despite presentation disease, we intuitively do expect long-term benefit from surgical primary tumor metastases already present. There noteworthy exceptions. Surgical removal lesion presence has renal cell carcinoma: Two radical nephrectomy improves treated initiallywith interferon formetastatic [1,2]. Survival stage III ovarian improved by maximal debulking, leaving only small-diameter nodules chemotherapy [3]. Roughly 70% who IV colorectal undergo resection; this based on other observational evidence nonetheless common clinical practice. Although metastasectomy