Method for inhibiting the development of Alzheimer's disease and related dementias- and for preserving cognitive function
作者： Doyle H. Waggle , Yuanlong Pan , Thomas Boston Clarkson , Michael R. Adams , Mary Susan Anthony
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摘要: Methods for inhibiting the development and relieving symptoms of Alzheimer's disease related dementias are provided. A phytoestrogenic isoflavone compound is administered to a human predisposed developing or dementia, having in an amount effective inhibit relieve disease. The selected from at least one genistein, genistin, 6'-OMal 6'-OAc daidzein, daidzin, glycitein, glycitin, mixtures thereof. up-regulate choline acetyltransferase mRNA nerve growth factor mRNA.
lens.org 参考文章(23)
Jerome L. Shen, Aglucone isoflavone enriched vegetable protein fiber ,(1994)
Sherwood L. Gorbach, Isoflavonoids for treatment and prevention of alzheimer dementia and reduced cognitive functions ,(1997)
John A. Eden, David C. Knight, A review of the clinical effects of phytoestrogens. Obstetrics & Gynecology. ,vol. 87, pp. 897- 904 ,(1996)
Ruth H. Pater, Renki Tashiro, Compositions and method of treating cardio-, cerebro-vascular and alzheimer's diseases and depression ,(1993)
Daniel Chajuss, A novel use of soy molasses ,(1996)
Hiroshi Ogawara, Noriki Ito, Shunichi Watanabe, Isoflavone derivatives, salts thereof, and oncostatic and immunosuppressive agents ,(1986)
Sherwood L. Gorbach, Barry R. Goldin, Herman Adlercreutz, Method for treatment of menopausal and premenstrual symptoms Official Gazette of the United States Patent and Trademark Office Patents. ,vol. 1184, pp. 1085- ,(1994)
Kenneth A. Faber, Claude L. Hughes, Dose-response characteristics of neonatal exposure to genistein on pituitary responsiveness to gonadotropin releasing hormone and volume of the sexually dimorphic nucleus of the preoptic area (SDN-POA) in postpubertal castrated female rats Reproductive Toxicology. ,vol. 7, pp. 35- 39 ,(1993) , 10.1016/0890-6238(93)90007-T
Peter Harrigan, Examining the benefits of dietary phytoestrogens Inpharma Weekly. ,vol. &NA;, pp. 3- 4 ,(1996) , 10.2165/00128413-199610660-00004
Thomas B. Clarkson, Mary S. Anthony, Claude L. Hughes, Estrogenic soybean isoflavones and chronic disease: Risks and benefits Trends in Endocrinology and Metabolism. ,vol. 6, pp. 11- 16 ,(1995) , 10.1016/1043-2760(94)00087-K