Phytoestrogenic formulations for alleviation or prevention of neurodegenerative diseases

摘要: Select phytoestrogen pharmaceutical compositions and methods of use for promoting neurological heath prevention age-related neurodegeneration, such as AD, have been developed. These select formulations are composed a number plant-derived estrogenic molecules and/or their structural analogues exhibit binding preference to ERβ over ERα agonist activity in the brain. ERβ-selective cross blood-brain-barrier promote estrogen-associated neurotrophism neuroprotections mechanisms brain, without activating proliferative reproductive tissues therefore devoid other problematic aspects. administered enterally, transdermally, transmucosally, intranasally or parenterally, dosage effective prevent alleviate neuronal damage, effect regeneration sustain viability, increase expression anti-apoptotic proteins, decrease indicators Alzheimer's Disease.