Thermal and Crystallographic Studies of 1-(2-Fluoro-4-Nitrophenyl)-4-(Prop-2-yn-1-yl)Piperazine Single Crystal
作者： Satish Kumar Awasthi , Chiranjeev Sharma , Monika Yadav , Gunjan Pandey
DOI: 10.1007/S40010-013-0102-8
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摘要: 1-(2-Fluoro-4-nitrophenyl)-4-(prop-2-yn-1-yl)piperazine was synthesized and single crystals were grown successfully by slow evaporation solution growth technique at room temperature. The compound characterized FTIR, 1H NMR 13C NMR. From X-ray crystallography the crystal structure is monoclinic having a space group P21/c corresponding lattice parameters, a = 9.7366(8) A, b = 17.9148(13) A, c = 7.5270(6) A β = 102.397 (8)°. Packing studies of reveal presence several intermolecular interactions viz., C–H···O hydrogen bonding, C(aryl)–H···π stacking aromatic rings which stabilize lattice. thermal stability determined TG–DTA DSC.
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Shailja Singh, Manavendra K. Singh, Alka Agarwal, Satish K. Awasthi, 2-(4-Chloro-phen-yl)chromen-4-one. Acta Crystallographica Section E-structure Reports Online. ,vol. 67, ,(2011) , 10.1107/S1600536811043832
Neesha Yadav, Sandeep K Dixit, Amit Bhattacharya, Lokesh C Mishra, Manish Sharma, Satish K Awasthi, Virendra K Bhasin, None, Antimalarial activity of newly synthesized chalcone derivatives in vitro. Chemical Biology & Drug Design. ,vol. 80, pp. 340- 347 ,(2012) , 10.1111/J.1747-0285.2012.01383.X
Bernadette Cusack, Albert Nelson, Elliott Richelson, Binding of antidepressants to human brain receptors: focus on newer generation compounds Psychopharmacology. ,vol. 114, pp. 559- 565 ,(1994) , 10.1007/BF02244985
Ali Khalaj, Maryam Nakhjiri, Amir Soheil Negahbani, Marjaneh Samadizadeh, Loghman Firoozpour, Saeed Rajabalian, Nasrin Samadi, Mohammad Ali Faramarzi, Neda Adibpour, Abbas Shafiee, Alireza Foroumadi, Discovery of a novel nitroimidazolyl–oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation European Journal of Medicinal Chemistry. ,vol. 46, pp. 65- 70 ,(2011) , 10.1016/J.EJMECH.2010.10.015
Ronald J. Mattson, John D. Catt, Daniel Keavy, Charles P. Sloan, James Epperson, Qi Gao, Donald B. Hodges, Lawrence Iben, Cathy D. Mahle, Elaine Ryan, Frank D. Yocca, Indanyl piperazines as melatonergic MT2 selective agents. Bioorganic & Medicinal Chemistry Letters. ,vol. 13, pp. 1199- 1202 ,(2003) , 10.1016/S0960-894X(03)00090-8
Philippe M. Manoury, Andre P. Dumas, Henry Najer, Dan Branceni, Monique Prouteau, Francoise M. Lefevre-Borg, Synthesis and analgesic activities of some (4-substituted phenyl-1-piperazinyl)alkyl 2-aminobenzoates and 2-aminonicotinates. Journal of Medicinal Chemistry. ,vol. 22, pp. 554- 559 ,(1979) , 10.1021/JM00191A017
R.P. Tripathi, V.K. Tiwari, S. Misra-Bhattacharya, K. Tyagi, V.M.L. Srivastava, P.K. Murthy, 7-O-[4-methyl piperazine-1-(2-acetyl)]-2H-1-benzopyran-2-one: a novel antifilarial lead compound. Acta Tropica. ,vol. 87, pp. 215- 224 ,(2003) , 10.1016/S0001-706X(03)00066-4
Chiranjeev Sharma Neupane, Satish Kumar Awasthi, Unique trifurcated hydrogen bonding in a pseudopolymorph of tricyclohexane triperoxide (TCTP) and its thermal studies Tetrahedron Letters. ,vol. 53, pp. 6067- 6070 ,(2012) , 10.1016/J.TETLET.2012.08.134
Robert A. Lyon, Milt Titeler, J. D. McKenney, Philip S. Magee, Richard A. Glennon, Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents Journal of Medicinal Chemistry. ,vol. 29, pp. 630- 634 ,(1986) , 10.1021/JM00155A008
Jayaram R. Tagat, Stuart W. McCombie, Ruo W. Steensma, Sue-Ing Lin, Dennis V. Nazareno, Bahige Baroudy, Nicole Vantuno, Serena Xu, Jia Liu, Piperazine-based CCR5 antagonists as HIV-1 inhibitors. I: 2(S)-methyl piperazine as a key pharmacophore element. Bioorganic & Medicinal Chemistry Letters. ,vol. 11, pp. 2143- 2146 ,(2001) , 10.1016/S0960-894X(01)00381-X