Inflammatory obstruction of the olfactory clefts and olfactory loss in humans: a new syndrome?

摘要: The first step in the olfactory perception is activation by odorants of sensory neurones epithelium. In humans, this epithelium located at 2 narrow passages, clefts, upper part nasal cavities. Little known about physiology these clefts. We examined, 34 patients, impact obstructed clefts upon detection and postlearning identification 5 odorants. location extension obstructions were assessed using endoscopy, CT scans, MRI. inflammatory obstruction was usually bilateral, extending anteroposteriorly, confined to with no sign or any disease rest cavities sinuses. When tested odorants, patients showed greatly impaired olfaction compared a group 73 normosmic subjects. majority had deficits equivalent that found another 41 congenital anosmic where inspection MRI indicated lack bulbs. This study demonstrates human, function as an entity different from other regions cavity target for local events are apparently not responding corticoid antibiotic treatments.