Association of terpinolene and diclofenac presents antinociceptive and anti-inflammatory synergistic effects in a model of chronic inflammation

摘要: Pharmacological treatment of inflammatory pain is usually done by administration non-steroidal anti-inflammatory drugs (NSAIDs). These present high efficacy, although side effects are common, especially gastrointestinal lesions. One the pharmacological strategies to minimize such combination and natural products with synergistic analgesic effect. The monoterpene terpinolene (TPL) a chemical constituent essential oils in many plant species, which have activities, as anti-inflammatory. association ineffective doses TPL diclofenac (DCF) (3.125 1.25 mg/kg po, respectively) presented antinociceptive acute (0, 1, 2, 3, 4, 5 6 h, after treatment) chronic (10 days) hyperalgesia induced Freund's complete adjuvant (CFA) right hind paw female Wistar rats (170-230 g, n=6-8). mechanical was assessed Randall Selitto pressure test, determines withdrawal thresholds. development edema quantified measuring volume plethismography. TPL/DCF reduced neutrophils, macrophages lymphocytes histological analysis paw, following standard staining protocol hematoxylin eosin counts were performed aid optical microscopy oral these drugs. Moreover, did not induce macroscopic gastric A possible mechanism action effect involvement 5-HT2A serotonin receptors, because ketanserin completely reversed association. results suggest that had without causing apparent injury, serotonergic system may be involved this