The Terroir of Cannabis: Terpene Metabolomics as a Tool to Understand Cannabis sativa Selections.

摘要: The phytochemical diversity of Cannabis chemovars is not well understood, and many were created in informal breeding programs without records parentage or the criteria for selection. Key selection sometimes included aroma notes visual cues, which some breeders associated with pharmacological activity. We hypothesized that process scents believed to be related specific tetrahydrocannabinol levels has resulted modified terpene biosynthesis these chemovars. Thirty-two cannabinoids, 29 monoterpenes 38 sesquiterpenes measured 33 from 5 licensed producers. A classification system based on cannabinoid content was used targeted metabolomic tools determine relationships phytochemistry. Three monoterpenes, limonene, β-myrcene, α-pinene, two sesquiterpenes, caryophyllene humulene, abundant majority Nine terpenes present tetrahydrocannabinol-dominant four predominantly found cannabidiol-containing Low abundance may have been aromatic cues identified by breeders. medicinal activity likely contribute effect Together, data demonstrate synergy compounds point need additional research understand complexity.