Alpha-Pinene Exhibits Anti-Inflammatory Activity Through the Suppression of MAPKs and the NF-κB Pathway in Mouse Peritoneal Macrophages
作者： Dae-Seung Kim , Hyun-Ja Lee , Yong-Deok Jeon , Yo-Han Han , Ji-Ye Kee
DOI: 10.1142/S0192415X15500457
关键词:
摘要: In this study, we found that alpha-pinene (α-pinene) exhibits anti-inflammatory activity through the suppression of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) pathway in mouse peritoneal macrophages. α-Pinene is oils many coniferous trees rosemary. We investigated inhibitory effects on inflammatory responses induced by lipopolysaccharide (LPS) using significantly decreased LPS-induced production interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), nitric oxide (NO). also inhibited inducible synthase (iNOS) cyclooxygenase-2 (COX-2) expressions LPS-stimulated Additionally, activations MAPKs NF-κB were attenuated means α-pinene treatment. These results indicate has an effect it a potential candidate as new drug to treat various diseases.
sci-hub.se 参考文章(32)
Beatrice Mercier, Josiane Prost, Michel Prost, THE ESSENTIAL OIL OF TURPENTINE AND ITS MAJOR VOLATILE FRACTION (α- AND β-PINENES): A REVIEW International Journal of Occupational Medicine and Environmental Health. ,vol. 22, pp. 331- 342 ,(2009) , 10.2478/V10001-009-0032-5
S Narumi, J H Finke, T A Hamilton, Interferon gamma and interleukin 2 synergize to induce selective monokine expression in murine peritoneal macrophages. Journal of Biological Chemistry. ,vol. 265, pp. 7036- 7041 ,(1990) , 10.1016/S0021-9258(19)39255-5
Mahmoud Z. El-Readi, Hanaa H. Eid, Mohamed L. Ashour, Safaa Y. Eid, Rola M. Labib, Frank Sporer, Michael Wink, Variations of the chemical composition and bioactivity of essential oils from leaves and stems of Liquidambar styraciflua (Altingiaceae). Journal of Pharmacy and Pharmacology. ,vol. 65, pp. 1653- 1663 ,(2013) , 10.1111/JPHP.12142
H. Takematsu, H. Ozawa, T. Yoshimura, M. Hara, A. Sakakibara, J. Oyama, H. Tagami, Systemic TNF administration in psoriatic patients: a promising therapeutic modality for severe psoriasis. British Journal of Dermatology. ,vol. 124, pp. 209- 210 ,(1991) , 10.1111/J.1365-2133.1991.TB00439.X
Ruslan Medzhitov, Charles A Janeway, Innate Immunity: The Virtues of a Nonclonal System of Recognition Cell. ,vol. 91, pp. 295- 298 ,(1997) , 10.1016/S0092-8674(00)80412-2
Jong-Bin Kim, Ah-Reum Han, Eun-Young Park, Ji-Yeon Kim, Woong Cho, Jun Lee, Eun-Kyoung Seo, Kyung-Tae Lee, Inhibition of LPS-Induced iNOS, COX-2 and Cytokines Expression by Poncirin through the NF-κB Inactivation in RAW 264.7 Macrophage Cells Biological & Pharmaceutical Bulletin. ,vol. 30, pp. 2345- 2351 ,(2007) , 10.1248/BPB.30.2345
Eui-Ju Hong, Ki-Jeung Na, In-Gyu Choi, Kyung-Chul Choi, Eui-Bae Jeung, Antibacterial and antifungal effects of essential oils from coniferous trees. Biological & Pharmaceutical Bulletin. ,vol. 27, pp. 863- 866 ,(2004) , 10.1248/BPB.27.863
Jeong-Ho Lee, Byung-Kyu Lee, Jong-Hee Kim, Sang Hee Lee, Soon-Kwang Hong, Comparison of chemical compositions and antimicrobial activities of essential oils from three conifer trees; Pinus densiflora, Cryptomeria japonica, and Chamaecyparis obtusa. Journal of Microbiology and Biotechnology. ,vol. 19, pp. 391- 396 ,(2009) , 10.4014/JMB.0803.191
Calin D Dumitru, Jeffrey D Ceci, Christos Tsatsanis, Dimitris Kontoyiannis, Konstantinos Stamatakis, Jun-Hsiang Lin, Christos Patriotis, Nancy A Jenkins, Neal G Copeland, George Kollias, Philip N Tsichlis, TNF-α Induction by LPS Is Regulated Posttranscriptionally via a Tpl2/ERK-Dependent Pathway Cell. ,vol. 103, pp. 1071- 1083 ,(2000) , 10.1016/S0092-8674(00)00210-5
Sun-Young Nam, Cha-kwon Chung, Jun-Ho Seo, So-Young Rah, Hyung-Min Kim, Hyun-Ja Jeong, The therapeutic efficacy of α-pinene in an experimental mouse model of allergic rhinitis. International Immunopharmacology. ,vol. 23, pp. 273- 282 ,(2014) , 10.1016/J.INTIMP.2014.09.010