Synthetic bile acids: novel mediators of apoptosis.

摘要: Summary and implications In this paper, we outlined the current understanding of naturaland synthetic bile acid signaling in apoptosis. Much insightwas gained recent years, particularly with respect to theinducers hydrophobic cascade.Moreover, newly synthesized acids also inducedapoptosis several human cancer cells, which were notderived from hepatocytes, cholangiocytes, ilealenterocytes. Therefore, new might beapplicable novel apoptosis mediators for treatment ofvarious cells.In breast prostate cells differenttumor suppressor p53 status, derivative-induced growth inhibition associated withthe up-regulation Bax p21 WAF1/CIP1 , effects weremediated via a p53-inpendent pathway. Jurkat T cellleukemia, derivatives induced apoptosisthrough caspase activation. Additionly, acidsinduced JNK dependent manner SiHa humancervical PC3 HT29 coloncancer TE671 brain tumor (Im, E.O., Yoo,Y.H., Kim, N.D., unpublished data).Alterations cell survival play critical role thepathogenesis various diseases, including cancer(Thompson, 1995). Administration modified thatinduce represent rational therapy tumorsthat originate different types cells. Therefore,these may promisingchemical entities, specifically target cancercells by triggering These could be important leadcompounds development anticancer agents thatare based on structure acids.Acknowledgments This work was supported grant No.R01-2001-00145 Korea Science & EngineeringFoundation Pusan National University ResearchGrant.