Recurrent chromosome aberrations in cancer.

摘要: Cytogenetic investigations of neoplastic cells during the past 25 years have revealed more than 600 acquired, recurrent, balanced chromosome rearrangements, and it has been established that every tumor type, studied in a sufficient number to permit conclusions, may be subdivided on basis specific, even pathognomonic, abnormalities. At molecular level, rearrangements exert their action through one two alternative mechanisms: Deregulation gene by relocation an immunoglobulin or T-cell receptor gene, creation hybrid fusion parts genes. present, nearly 100 genes found involved neoplasia-associated chromosomal great majority hematological disorders. same time, clinical usefulness various cytogenetic abnormalities as diagnostic prognostic aids increasingly appreciated. The identification recurring abnormality can assist diagnosis subclassification malignant disease and, hence, selection appropriate treatment. karyotype is also independent factor. In neoplasms, where knowledge still much complete case with solid tumors, analysis now plays integral part work-up individual patients. Data obtained recent strongly suggest corresponding breakthroughs will achieved tumors within not-too-distant future.