Extracellular HSP70 binding to surface receptors present on antigen presenting cells and endothelial/epithelial cells

作者: Jimmy R. Thériault , Salamatu S. Mambula , Tatsuya Sawamura , Mary Ann Stevenson , Stuart K. Calderwood

DOI: 10.1016/J.FEBSLET.2005.02.046

关键词:

摘要: Extracellular HSP70 has been found to participate in both innate and adaptive immune responses. However, little is known about the molecular mechanisms that mediate this process. Previous reports suggest interacts with antigen presenting cells (APC) through a plethora of surface receptors. In study, we have examined relative binding potential receptors high affinity LOX-1 but not other structures role HSP70–APC interactions such as LRP/CD91, CD40, TLR2, TLR4 or another c-type lectin family member (DC-SIGN) closely related LOX-1. addition APC, can avidly bind non-APC cell lines, especially those from epithelial endothelial background.

参考文章(51)
Kathy Triantafilou, Martha Triantafilou, Russell L. Dedrick, A CD14-independent LPS receptor cluster Nature Immunology. ,vol. 2, pp. 338- 345 ,(2001) , 10.1038/86342
Alexzander Asea, Stine-Kathrein Kraeft, Evelyn A. Kurt-Jones, Mary Ann Stevenson, Lan Bo Chen, Robert W. Finberg, Gloria C. Koo, Stuart K. Calderwood, HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nature Medicine. ,vol. 6, pp. 435- 442 ,(2000) , 10.1038/74697
Robert J. Binder, David K. Han, Pramod K. Srivastava, CD91: a receptor for heat shock protein gp96. Nature Immunology. ,vol. 1, pp. 151- 155 ,(2000) , 10.1038/77835
Lynn M. Obermoeller-McCormick, Yonghe Li, Hiroshi Osaka, Guojun Bu, Alan L. Schwartz, David J. FitzGerald, Dissection of receptor folding and ligand-binding property with functional minireceptors of LDL receptor-related protein Journal of Cell Science. ,vol. 114, pp. 899- 908 ,(2001)
Miguel Relloso, Amaya Puig-Kröger, Oscar Muñiz Pello, José Luis Rodríguez-Fernández, Gonzalo de la Rosa, Natividad Longo, Joaquín Navarro, Mari Angeles Muñoz-Fernández, Paloma Sánchez-Mateos, Angel L. Corbí, DC-SIGN (CD209) Expression Is IL-4 Dependent and Is Negatively Regulated by IFN, TGF-β, and Anti-Inflammatory Agents The Journal of Immunology. ,vol. 168, pp. 2634- 2643 ,(2002) , 10.4049/JIMMUNOL.168.6.2634
Shyra J. Gardai, Yi-Qun Xiao, Matthew Dickinson, Jerry A. Nick, Dennis R. Voelker, Kelly E. Greene, Peter M. Henson, By Binding SIRPα or Calreticulin/CD91, Lung Collectins Act as Dual Function Surveillance Molecules to Suppress or Enhance Inflammation Cell. ,vol. 115, pp. 13- 23 ,(2003) , 10.1016/S0092-8674(03)00758-X
Flora Castellino, Philip E. Boucher, Katrin Eichelberg, Mark Mayhew, James E. Rothman, Alan N. Houghton, Ronald N. Germain, Receptor-Mediated Uptake of Antigen/Heat Shock Protein Complexes Results in Major Histocompatibility Complex Class I Antigen Presentation via Two Distinct Processing Pathways Journal of Experimental Medicine. ,vol. 191, pp. 1957- 1964 ,(2000) , 10.1084/JEM.191.11.1957
Maria C. Kuppner, Robert Gastpar, Svetlana Gelwer, Elfriede Nössner, Oswin Ochmann, Anabel Scharner, Rolf D. Issels, The role of heat shock protein (hsp70) in dendritic cell maturation: hsp70 induces the maturation of immature dendritic cells but reduces DC differentiation from monocyte precursors. European Journal of Immunology. ,vol. 31, pp. 1602- 1609 ,(2001) , 10.1002/1521-4141(200105)31:5<1602::AID-IMMU1602>3.0.CO;2-W
Tatsuya Sawamura, Noriaki Kume, Takuma Aoyama, Hideaki Moriwaki, Hajime Hoshikawa, Yuichi Aiba, Takeshi Tanaka, Soichi Miwa, Yoshimoto Katsura, Toru Kita, Tomoh Masaki, An endothelial receptor for oxidized low-density lipoprotein Nature. ,vol. 386, pp. 73- 77 ,(1997) , 10.1038/386073A0