作者: Jimmy R. Thériault , Salamatu S. Mambula , Tatsuya Sawamura , Mary Ann Stevenson , Stuart K. Calderwood
DOI: 10.1016/J.FEBSLET.2005.02.046
关键词:
摘要: Extracellular HSP70 has been found to participate in both innate and adaptive immune responses. However, little is known about the molecular mechanisms that mediate this process. Previous reports suggest interacts with antigen presenting cells (APC) through a plethora of surface receptors. In study, we have examined relative binding potential receptors high affinity LOX-1 but not other structures role HSP70–APC interactions such as LRP/CD91, CD40, TLR2, TLR4 or another c-type lectin family member (DC-SIGN) closely related LOX-1. addition APC, can avidly bind non-APC cell lines, especially those from epithelial endothelial background.