Circulating HSP70 as an Endogenous Cytoprotector

摘要: Although classically regarded as being an intracellular molecular chaperone, many studies have reported that the 70 kDa stress protein can be released from a number of different cell types in absence death. Furthermore, we and others presence Hsp70 circulation normal individuals, levels this peripheral increased by physical psychological stressors. The question is: what is physiological role circulating Hsp70? Extracellular has been to neuroprotective cytoprotective properties, shown high serum protect individuals with hypertension development progression cardiovascular disease. It might therefore extracellular members family multiple roles maintenance homeostasis which extend beyond their more commonly accepted properties immunoregulatory molecules. Perhaps ubiquitous proteins could also considered exogenous cytoprotectors.