Alternative Mechanism by which IFN-γ Enhances Tumor Recognition: Active Release of Heat Shock Protein 72
作者： Maria A. Bausero , Robert Gastpar , Gabriele Multhoff , Alexzander Asea
DOI: 10.4049/JIMMUNOL.175.5.2900
关键词:
摘要: … IFN-γ is used in combination with ILs (20). Treatment of tumor cells with IFN-γ in vitro induces cell … + CTL to kill the tumor. Released Hsp72 stimulate migratory and cytolytic activity in NK …
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Alexzander Asea, Stine-Kathrein Kraeft, Evelyn A. Kurt-Jones, Mary Ann Stevenson, Lan Bo Chen, Robert W. Finberg, Gloria C. Koo, Stuart K. Calderwood, HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nature Medicine. ,vol. 6, pp. 435- 442 ,(2000) , 10.1038/74697
K.A. Hutchison, K.D. Dittmar, M.J. Czar, W.B. Pratt, Proof that hsp70 is required for assembly of the glucocorticoid receptor into a heterocomplex with hsp90. Journal of Biological Chemistry. ,vol. 269, pp. 5043- 5049 ,(1994) , 10.1016/S0021-9258(17)37651-2
Edward L. Schwartz, Scott Wadler, Antineoplastic activity of the combination of interferon and cytotoxic agents against experimental and human malignancies: a review. Cancer Research. ,vol. 50, pp. 3473- 3486 ,(1990)
Yufei Wang, Trevor Whittall, Edward McGowan, Justine Younson, Charles Kelly, Lesley A. Bergmeier, Mahavir Singh, Thomas Lehner, Identification of stimulating and inhibitory epitopes within the heat shock protein 70 molecule that modulate cytokine production and maturation of dendritic cells. Journal of Immunology. ,vol. 174, pp. 3306- 3316 ,(2005) , 10.4049/JIMMUNOL.174.6.3306
Naveed N. Panjwani, Lana Popova, Pramod K. Srivastava, Heat Shock Proteins gp96 and hsp70 Activate the Release of Nitric Oxide by APCs The Journal of Immunology. ,vol. 168, pp. 2997- 3003 ,(2002) , 10.4049/JIMMUNOL.168.6.2997
G Multhoff, R Issels, J Ellwart, C Botzler, L Jennen, J Schmidt, Heat shock protein 72 on tumor cells: a recognition structure for natural killer cells. Journal of Immunology. ,vol. 158, pp. 4341- 4350 ,(1997)
Joseph Wolfers, Anne Lozier, Graça Raposo, Armelle Regnault, Clotilde Théry, Carole Masurier, Caroline Flament, Stéphanie Pouzieux, Florence Faure, Thomas Tursz, Eric Angevin, Sebastian Amigorena, Laurence Zitvogel, Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nature Medicine. ,vol. 7, pp. 297- 303 ,(2001) , 10.1038/85438
Robert Gastpar, Catharina Gross, Lydia Rossbacher, Joachim Ellwart, Julia Riegger, Gabriele Multhoff, The Cell Surface-Localized Heat Shock Protein 70 Epitope TKD Induces Migration and Cytolytic Activity Selectively in Human NK Cells Journal of Immunology. ,vol. 172, pp. 972- 980 ,(2004) , 10.4049/JIMMUNOL.172.2.972
Alexzander Asea, Chaperokine-Induced Signal Transduction Pathways Exercise Immunology Review. ,vol. 9, pp. 25- 33 ,(2003)
Carmen Ruiz-Ruiz, Abelardo López-Rivas, Cristina Muñoz-Pinedo, Interferon-{{gamma}} Treatment Elevates Caspase-8 Expression and Sensitizes Human Breast Tumor Cells to a Death Receptor-induced Mitochondria-operated Apoptotic Program Cancer Research. ,vol. 60, pp. 5673- 5680 ,(2000)