Hsp70: Anti-apoptotic and Tumorigenic Protein

摘要: Heat shock protein 70 (Hsp70) is a powerful chaperone whose expression induced in response to wide variety of physiological and environmental insults, including anticancer chemotherapy, thus allowing the cell survive lethal conditions. Hsp70 cytoprotective properties may be explained by its anti-apoptotic function. Indeed, this can inhibit key effectors apoptotic machinery at pre- postmitochondrial level. In cancer cells, abnormally high, participate oncogenesis resistance chemotherapy. rodent models, overexpression increases tumor growth metastatic potential. Depletion or inhibition frequently reduces size tumors even cause their complete involution. But also found extracellular medium. Its role then immunogenic term chaperokine define chaperones has been advanced. tumorigenic functions as well strategies that are being developed therapy order commented chapter.