Re-evaluating the role of heat-shock protein-peptide interactions in tumour immunity.

摘要: Early investigations into the immune surveillance of chemically-induced sarcomas led to two important concepts in tumour immunobiology: one, rejection can be elicited by recognition antigens; and two, tumours express unique sets antigens, which are known as tumour-specific antigens. The pioneering studies Srivastava colleagues proposal that heat-shock proteins (HSPs) function ubiquitous with specificity residing a population bound peptides identify tissue origin HSP. However, recent findings, including new data on cell biology peptide generation trafficking, have called question is induced HSPs.